6 edition of GTPases regulating membrane targeting and fusion found in the catalog.
Includes bibliographical references and index.
|Statement||edited by William E. Balch, Channing J. Der, Alan Hall.|
|Series||Methods in enzymology -- v. 403.|
|Contributions||Balch, William Edward, 1949-, Der, Channing J., Hall, A.|
|LC Classifications||QP601 .M49 vol. 403|
|The Physical Object|
|Pagination||xliii, 863 p.,  p. of plates :|
|Number of Pages||863|
Protein targeting to the plasma membrane of adult skeletal muscle fiber: An organized mosaic of functional domains. Rahkila, P., Takala, T. E. S., Parton, R. G. and Metsikko, K. () Protein targeting to the plasma membrane of adult skeletal muscle fiber: An organized mosaic of functional domains. The RAB and ARF GTPases are members of two of the RAS-related subfamilies that function in regulating vesicle trafficking, starting from regulating the formation of vesicles on donor membranes and directing trafficking specificity to and facilitating vesicle docking on target membranes (Zerial and McBride, ; Gillingham and Munro, ).
Rab GTPases represent a family of key membrane traffic regulators in eukaryotic cells. To exert their function, Rab proteins must be modified with one or two geranylgeranyl moieties. This modification enables them to reversibly associate with intracellular by: 6. Rab GTPases and Membrane Trafficking. Editor(s): Guangpu Li and Nava Segev DOI: / eISBN: , ISBN: Indexed in: BIOSIS Previews, Chemical Abstracts, Scopus, EBSCO. Recommend this Cited by: 3.
Pollen tube elongation depends on the secretion of large amounts of membrane and cell wall materials at the pollen tube tip to sustain rapid growth. A large family of RAS-related small GTPases, Rabs or Ypts, is known to regulate both anterograde and retrograde trafficking of transport vesicles between different endomembrane compartments and the plasma membrane Cited by: In the cytosol of plant cells vesicle transport occurs via secretory pathways among the endoplasmic reticulum network, Golgi bodies, secretory granules, endosome, and plasma membrane. Three systems transfer lipids, proteins and other important molecules through aqueous spaces to membrane-enclosed compartments, via vesicles that bud from donor Cited by:
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GTPases Regulating Membrane Targeting and Fusion. William E. Balch, Channing J. Der, and Alan Hall Show all chapter previews Show all chapter previews. Receive an update when the latest chapters in this book series are published article Application of Protein Semisynthesis for the Construction of Functionalized Posttranslationally.
COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle.
Purchase GTPases Regulating Membrane Targeting and Fusion, Volume - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Studies on the mechanisms involved in membrane targeting and intracellular trafficking of the AA transporters in intestinal epithelial cells have begun to emerge.
Confocal imaging studies and video rate measurements using live human intestinal epithelial Caco-2 cells grown on filters and fusion proteins of hSVCT-1 with the yellow. THE CONSERVED STRUCTURE OF Rabs. Rabs constitute the largest family of small Ras-like GTPases with 11 identified in yeast and more than 60 members in humans that can be classified in several phylogenetic and functional groups (, ).The structures of at least 16 different Rab proteins in either their active (GTP-bound) or inactive (GDP-bound) state have been Cited by: The present work suggests the following insights into the mechanisms regulating the membrane-association of Rab GTPases: 1) di-geranylgeranylation is required for targeting and function of Rab5a and Rab27a to endosomes and melanosomes, respectively, because mono-geranylgeranylated mutants are mistargeted to ER membranes and are unable to Cited by: Regulation of Membrane Transport by rab GTPases Article Literature Review in Critical Reviews in Biochemistry and Molecular Biology 38(2) February with 26 Reads.
The Ras superfamily (> human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission.
The Ras (Ra t s arcoma) superfamily of small GTPases is an ancient group of molecular switches whose functions have radiated phylogenetically to encompass broad areas of cell founding members of the superfamily are the Ras proto-oncogenes, discovered in the early s, which are conserved from yeast to C.
elegans, Drosophila, and mammals. Methods in enzymology by Sidney P. Colowick,Academic Press edition, in English GTPases regulating membrane targeting and fusion. v GTPases regulating membrane dynamics.
v Mass spectrometry: modified proteins and glycoconjugates. As part of the Plant Physiology focus issue on membrane biology, this review focuses on subcellular targeting of plant ROP/RAC GTPases and on the role of these proteins in the regulation of membrane trafficking, cytoskeleton organization, and cell polarity.
Other aspects of ROP/RAC biology, such as the role of these GTPases in hormonal or. Extracellular Vesicles, Volume in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by leaders in the field.
Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of.
Abstract. Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and there are 66 Rab genes in the human genome. They alternate between GTP- and GDP-bound states, which are facilitated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and function as molecular switches in regulation of intracellular Cited by: Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more.
Multiple regions contribute to membrane targeting of Rab GTPases Article in Journal of Cell Science (Pt 26) January with 17 Reads How we measure 'reads'. As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases coordinate a wide range of biological processes such as cell adhesion, motility, and polarity.
In the last years, Rho GTPases have also been recognized to control intracellular membrane sorting and trafficking steps directly; however, how Rho GTPase signaling is regulated at endomembranes is still Author: Monilola A. Olayioye, Bettina Noll, Angelika Hausser.
Small GTPases in Membrane Processes: Trafficking, Autophagy and Disease SeptemberNational Conference Center, Leesburg VA Co-Organizers: Nava Segev University of Illinois at Chicago Chicago, ILUSA Marino Zerial Max Planck Institute of Molecular Cell Biology and Genetics, MPI-CBG Dresden, Germany Program.
The GTPase switch appears to be almost as old as life itself, and nature has adapted it to a variety of purposes. This two-volume work surveys the major classes of GTPases, including their role in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle.
We showed earlier that well-defined synthetic membrane domains not only recruit AP-1A coats, including ARF-1 and its specific effectors, but also a machinery regulating actin nucleation (Rac-1, its effectors, and the Wave/Scar complex) and the Rab11 and Rab14 GTPases regulating membrane dynamics between the TGN and endosomes (Baust et al., Lindsay, AJ;McCaffrey, MW () 'Purification and functional properties of RabFIP2' In: GTPASES REGULATING MEMBRANE TARGETING AND FUSION.
SAN DIEGO: ELSEVIER ACADEMIC PRESS INC. () 'Rab Family' McCaffrey M.W., Lindsay A.J. () 'Rab Family' In: Encyclopedia of Biological Chemistry. London: Elsevier.
(). Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In humans six family members are known to date, namely mammalian/mechanistic target of rapamycin (mTOR), ataxia-telangiectasia Cited by: Marzesco, A.
M., & Zahraoui, A. (). Assay of Rab13 in regulating epithelial tight junction assembly. In GTPASES REGULATING MEMBRANE TARGETING AND FUSION (pp. ). SAN DIEGO: ELSEVIER ACADEMIC PRESS by: 2.Bottom Line: Small GTPases play crucial roles in the differentiation, function, and survival of tanding the roles of individual small GTPases in osteoclast biology may lead to more targeted therapies for the treatment of low bone this review, we discuss recent investigations into the in vivo effects of individual GTPase deletion in osteoclasts and the .